Kidney Failure May Drive COVID Deaths in People With Sickle
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COVID-19 patients with sickle cell trait (SCT) were prone to poor outcomes that appeared to be driven in part by kidney dysfunction, a genetic association study suggested. In this study of 2729 persons with SCT and 129?848 who were SCT negative, individuals with SCT had a number of preexisting kidney conditions that were associated with unfavorable outcomes following COVID-19. The presence of SCT was associated with increased risk of mortality and acute kidney failure following COVID-19. Results strongly support the inclusion of SCT as an adverse prognostic factor for COVID-19.