Kidney Injury in Anticoagulated Asians With Atrial Fibrillat
What is the risk of acute kidney injury (AKI) associated with warfarin compared with dabigatran?

Methods:
This was a retrospective cohort study based on data obtained from the Taiwan National Health Insurance Registry Database. The study included 7,702 and 7,885 patients without prior kidney disease who were treated with dabigatran and warfarin, respectively, and 2,256 and 2,089 patients with chronic kidney disease (CKD) treated with dabigatran and warfarin, respectively. AKI was defined as an increase in serum creatinine of ?0.3 mg/dl, a ?50% increase in serum creatinine, or oliguria within 48 hours. The mean follow-up was approximately 8.5 months.

Results:
Among patients without CKD, the incidence of AKI was 2.17 and 3.47/100 person-years in the dabigatran and warfarin groups, respectively. Among patients with CKD, the incidence of AKI was 9.28 and 16.21/100 person-years in the dabigatran and warfarin groups, respectively. The incidence of AKI was significantly lower in the dabigatran group than in the warfarin group, both in patients with (hazard ratio [HR], 0.56) and without (HR, 0.62) CKD.....


http://www.acc.org/latest-in-cardiology/journal-scans/2016/11/21/14/41/acute-kidney-injury-in-asians-with-atrial-fibrillation?
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