Kids' Brains Affected by COVID-Linked Inflammatory Syndrome-
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Neurologic findings in adult COVID-19 patients were also observed in some pediatric inflammatory multisystem syndrome (PIMS) cases that follow exposure to the virus, with brain imaging showing the impact, researchers reported.

New-onset neurological symptoms turned up in four of 27 (14.8%) previously healthy children in a PIMS case series reported by University College London, and colleagues in JAMA Neurology.

Those symptoms included encephalopathy and global muscle weakness in all four children along with:

- Headache in three children
- Brainstem signs with dysarthria or dysphagia in two children
- Reduced reflexes in two children
- Meningism in one child
- Cerebellar ataxia in one child

Neuroimaging showed signal changes in the splenium of the corpus callosum (SCC) region of the brain in all four PIMS patients with neurological symptoms. While T2-hyperintense lesions associated with restricted diffusion were seen in three, the fourth patient had a splenial lesion on CT that subsequent MRI didn't show as restricted diffusion.

"Reversible lesions of the SCC are rare but have been previously reported in patients with encephalopathies and are thought to represent focal intramyelin edema secondary to inflammation," the researchers noted.

A transient lesion in the SCC, "either in isolation or with more extensive brain involvement, has also been reported in children with Kawasaki disease," they added. Kawasaki disease overlaps with PIMS or MIS-C in a number of cases.

While the imaging finding has been seen with other viral infections, "clinicians should be adding SARS-CoV-2 to their differential diagnosis for children presenting with new neurologic symptoms and this imaging finding while still exploring other possible causes," Researchers argued.

Source; https://jamanetwork.com/journals/jamaneurology/fullarticle/2767979
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