Labrune Syndrome: A Unique Leukoencephalopathy
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The association of extensive cerebral calcification, white matter changes, and cysts is an entity described by Labrune et al., in 1996 as LCC. It is extremely rare with only 10 cases reported so far in the medical literature. It has been reported from around the world in children and adults, with onset up to 59 years. The ubiquitous presentation with seizures and progressive neurodeficit in a child invites a huge list of differential diagnoses, but the classical radiological features make the diagnosis of LCC unmistakable.

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