Large study confirms vitamin D does not reduce risk of depre
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Vitamin D supplementation does not protect against depression in middle-age or older adulthood according results from one of the largest ever studies of its kind. This is a longstanding question that has likely encouraged some people to take the vitamin.

This study aimed to test the effects of vitamin D3 supplementation on late-life depression risk and mood scores.

There were 18353 men and women aged 50 years or older in the VITAL-DEP (Vitamin D and Omega-3 Trial-Depression Endpoint Prevention) ancillary study to VITAL, a randomized clinical trial of cardiovascular disease and cancer prevention among 25871 adults.

There were 16657 at risk for incident depression (ie, no depression history) and 1696 at risk for recurrent depression (ie, depression history but no treatment for depression within the past 2 years).

Results:
- Among the 18353 randomized participants, the median treatment duration was 5.3 years and 90.5% completed the trial.
- Risk of depression or clinically relevant depressive symptoms was not significantly different between the vitamin D3 group and the placebo group; there were no significant differences between groups in depression incidence or recurrence.
- No significant differences were observed between treatment groups for change in mood scores over time; mean change in PHQ-8 score was not significantly different from zero.

Conclusively, Among adults aged 50 years or older without clinically relevant depressive symptoms at baseline, treatment with vitamin D3 compared with placebo did not result in a statistically significant difference in the incidence and recurrence of depression or clinically relevant depressive symptoms or for change in mood scores over a median follow-up of 5.3 years. These findings do not support the use of vitamin D3 in adults to prevent depression.

Source: https://jamanetwork.com/journals/jama/article-abstract/2768978
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