Large study finds no link between blood pressure medication
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There is no evidence that blood pressure lowering drugs increase the risk of cancer, according to the most extensive study conducted on the topic. The late breaking research is presented at ESC Congress 2020.

A potential link between blood pressure drugs and cancer has been debated for more than 40 years. The evidence for an increased or decreased risk of cancer with the use of antihypertensive medication has been inconsistent and conflicting.

This was the largest study on cancer outcomes in participants of randomised trials investigating antihypertensive medication - around 260,000 people in 31 trials. Investigators of all trials were asked for information on which participants developed cancer.

Five antihypertensive drug classes were investigated separately: angiotensin-converting enzyme (ACE) inhibitors, angiotensin II receptor blockers (ARBs), beta blockers, calcium channel blockers (CCBs), and diuretics.

The investigators estimated the effect of each drug class on the risk of developing any type of cancer, of dying from cancer, and of developing breast, colorectal, lung, prostate and skin cancers. They also examined whether there were any differences according to age, gender, body size, smoking status and previous antihypertensive medication use before taking part in the trial.

During an average of four years, there were around 15,000 new diagnoses of cancer. The researchers found no evidence that the use of any antihypertensive drug class increased the risk of cancer. This finding was consistent regardless of age, gender, body size, smoking status and previous antihypertensive medication use.

There was no important effect of any individual drug class on overall cancer risk. Similarly, there was no evidence that any type of antihypertensive medication had an effect on the probability of developing breast, colorectal, lung, prostate or skin cancer.

When participants were followed throughout the course of each trial, there was no indication that the risk of cancer increased with longer duration of use of these treatments.

Source: https://www.escardio.org/The-ESC/Press-Office/Press-releases/Large-study-finds-no-link-between-blood-pressure-medication-and-cancer
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