Largest-ever pre-adolescent brain activation study reveals c
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Youth brain activation data from the largest longitudinal neuroimaging study to date provides valuable new information on the cognitive processes and brain systems that underlie adolescent development and might contribute to mental and physical health challenges in adulthood. The study published in Nature Neuroscience.

Because of the notable brain, cognitive, and emotional maturation—and the emergence of many mental health disorders—that occurs between the ages of 10 and 20, understanding neurodevelopment and how it is impacted by the numerous risk factors that emerge during this timeframe is a critical area of interest. However, to date, most human neuroimaging studies have focused on adult functioning.

The Adolescent Brain Cognitive Development Study (ABCD) Study is a multisite, 10-year-long longitudinal study that has enrolled nearly 12,000 youth aged 9 to 10 at 21 research sites around the country.

These latest findings demonstrate which brain regions are involved in a range of important psychological processes, including cognitive control, reward processing, working memory, and social/emotional function.

Using functional magnetic resonance imaging (fMRI) technology, the researchers observed brain activation during a battery of three different tasks and identified how differences in the patterns of activity related to individual differences in these processes.

"This study shows the brain regions activated by each task, how well they capture individual differences, and will likely serve as a baseline for all the subsequent papers that will track the kids as they age."

The brain maps aim to improve scientists' understanding of the psychological processes that put young people at higher risk for developing mental and physical health challenges and, by identifying the brain correlates of factors that influence development, can give guidance on which interventions could help improve outcomes.

Source: DOI: 10.1038/s41593-021-00867-9