Late Onset Foreign Body Reaction due to Poly-L-Lactic Acid F
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Correction of aging changes and contour deformities has been a general issue for decades. Various materials have been used as tissue augmentation agents by administering into the tissues. Considering the stability of PLLA and ease of procedure, PLLA filler injection is often performed for the management of facial aging.

A 57-year-old female patient presented with asymptomatic skin-colored firm nodules on both the cheeks, which had persisted for one month. She had a history administration of PLLA filler injection for restoration of facial volume at these sites 18 months back. Physical examination revealed multiple, bilaterally distributed, well-marginated, round-shaped, and firm skin-colored nodules on both the cheeks. Histopathological examination of the cheek revealed non-caseating granulomas consisting of histiocytes with central foreign bodies in the dermis.

The patient was treated with two courses of 20 mg/ml triamcinolone intralesional injections in the lesions at a 2-weeks interval. Subsequent to treatment, complete disappearance of the palpable nodules was observed. No recurrence of the lesions was observed for 2 years.

Source: https://www.anndermatol.org/DOIx.php?id=10.5021/ad.2020.32.6.519
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