Late postnatal dexamethasone on weaning from invasive mechan
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A Study was conducted to evaluate the short-term respiratory effects of postnatal dexamethasone (PND) in a cohort of ventilator-dependent premature infants.

Clinical data from 106 infants 23–28 weeks gestation who received PND for weaning from Mechanical Ventilation were evaluated. PND was started at a dose of 0.1?mg/kg/d tapered over 5–7 d. Treatment success was defined as extubated and free from MV on d14 after start of treatment.

Result:
-Treatment was successful in 83 infants.
-Demographics and age of treatment did not differ between groups. In the failure group, a higher proportion were on HFOV and FiO2 more than 0.50 before treatment, compared to the successful group.

PND, in instance, led in effective weaning from Mechanical Ventilation in the majority of infants. Reduced oxygen requirements in non-extubated newborns may be advantageous, although it is unclear if this outweighs the hazards. It is necessary to assess the long-term impact of PND in ventilator-dependent newborns.

Source: https://www.nature.com/articles/s41372-021-01108-4
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