Left Ventricular Diastolic Dysfunction among Youth with Obes
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A Study was conducted to assess the prevalence of and factors associated with left ventricular diastolic dysfunction (LVDD) in youth with obesity and elevated blood pressure (BP).

A cross-sectional study of 83 youth aged 5 to 21 years who were tested for overweight/obesity and elevated blood pressure in a multidisciplinary clinic. On the basis of data from 103 age-sex matched healthy controls, LVDD was specified according to existing adult and pediatric criteria. Wilcoxon rank sum and Chi-square tests were used to look at the baseline variables associated with LVDDpeds. The associations of adiposity and blood pressure with LVDDpeds were studied using multiple logistic regression methods with generalized estimation equations to account for repeated steps.

--The prevalence of LVDD ranged from 1.2-2.7% using adult criteria and 19-28% using pediatric criteria.

--Those with LVDDpeds were older, predominantly male and non-African American, and had higher weight, BP, BP medication use, and non-HDL cholesterol than those without LVDDpeds.

--DBP z-score was associated with LVDDpeds by E/A (OR 1.95) after adjustment for age, sex, race, BP medications and BMI z-score.

Finally, using pediatric guidelines, LVDD was observed in a large proportion of children and teenagers who were overweight or obese and had high blood pressure. When compared to those without LVDD peds, those with LVDDpeds had substantially higher measures of adiposity and blood pressure, and DBP z-score was an independent indicator of LVDDpeds by E/A. These findings highlight the significance of preventing and treating CVD risk factors in children.

Source: https://www.jpeds.com/article/S0022-3476(21)00315-2/fulltext?rss=yes