Left atrial myxoma in a patient with hypertrophic obstructiv
A 50-year-old man presented with a history of recurrent syncope for the past 3 months, unrelated to exertion and occurred in the upright posture. No history of chest pain, dyspnea, or palpitation, any comorbidities and no family history of sudden cardiac death (SCD). On examination a midsystolic murmur in the lower left sternal border which increased in intensity with standing and strain phase of the Valsalva maneuver. His electrocardiogram showed left ventricular hypertrophy with a strain pattern. A provisional diagnosis of HOCM was made and echo was done- showed typical features of HOCM. HOCM and myxoma were reported separately in patients with LEOPARD syndrome. LEOPARD syndrome is defined by lentigines in combination with at least two other hallmarks: electrocardiographic conduction abnormalities, ocular hypertelorism, structural cardiac abnormalities, abnormal genitalia, retarded growth, and deafness.

Source: https://www.jcpconline.org/article.asp?issn=2250-3528;year=2022;volume=11;issue=2;spage=60;epage=62;aulast=Narayanapillai