Leukoreduction
Dr. Prashant Kumar
Leukoreduction
Cochrane Review/ 2015

 

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Leukoreduction for the prevention of adverse reactions from allogeneic blood transfusion

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Background:

 

A blood transfusion is an acute intervention, implemented to solve life and health-threatening conditions on a short-term basis.

However, blood transfusions have adverse events, some of them potentially related to immune modulation or to a direct transmission

of infectious agents (e.g. cytomegalovirus).

 

Leukoreduction is a process in which the white blood cells are intentionally reduced in packed red blood cells (PRBCs) in order to reduce the risk of adverse reactions. The potential bene?ts of leukoreduced PRBCs in all types of transfused patients for decreasing infectious and non-infectious complications remain unclear.

 

  Clinical Question:

 

What are the bene?ts and harms of removing white blood cells from donated blood for people receiving a blood transfusion?

 

  Authors’ Conclusions:

 

There is NO CLEAR EVIDENCE FOR SUPPORTING OR REJECTING the ROUTINE USE OF LEUKOREDUCTION in all patients requiring PRBC transfusion for preventing TRALI, death, infection, non-infectious complications and other adverse events. As the quality of evidence is very low to low, more evidence is needed before a de?nitive conclusion can be drawn.

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https://www.dropbox.com/s/fyickmjf1ef0z2h/Leukoreduction for the prevention of adverse reactions from allogeneic blood transfusion.pdf?dl=0

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