Lifestyle Interventions May Cut Down Gout Incidence In Men:
Now open: Certificate Course in Management of Covid-19 by Govt. Of Gujarat and PlexusMDKnow more...Now open: Certificate Course in Management of Covid-19 by Govt. Of Gujarat and PlexusMDKnow more...
The population impact of modifying obesity and other key risk factors for hyperuricemia has been estimated in cross-sectional studies; however, the proportion of incident gout cases (a clinical end point) that could be prevented by modifying such factors has not been evaluated. To estimate the proportion of incident gout cases that could be avoided through simultaneous modification of obesity and other key risk factors a study was conducted.

The Health Professionals Follow-up Study is a US prospective cohort study of 51529 male health professionals enrolled in 1986 and followed up through questionnaires every 2 years through 2012. Self-reported gout cases were confirmed through June 2015.

From data collected in the validated questionnaires, men were categorized to low-risk groups according to combinations of the following 4 factors:
-normal body mass index (BMI less than 25),
-no alcohol intake,
-adherence to Dietary Approaches to Stop Hypertension (DASH)–style diet (highest quintile of DASH diet score),
-no diuretic use.

44654 men (mean [SD] age, 54.0 years) with no history of gout at baseline were analyzed. During 26 years of follow-up, 1741 developed incident gout. Among all participants, PAR for the 4 risk factors combined (BMI, diet, alcohol use, and diuretic use) was 77%. Among men with normal weight (BMI less than 25) and overweight (BMI 25.0-29.9), researchers estimated that more than half of incident gout cases (69% and 59%) may have been prevented by the combination of DASH-style diet, no alcohol intake, and no diuretic use. However, among men with obesity (BMI more than 30), PAR was substantially lower and not significant (5%).

The findings of this cohort study suggested that addressing excess adiposity and other key modifiable factors has the potential to prevent the majority of incident gout cases among men. Men with obesity may not benefit from other modifications unless weight loss is addressed.

Source: https://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2020.27421
Like
Comment
Share