Link Between Milk Fat Globule-Epidermal Growth Factor 8 and
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A Study was conducted to investigate the relationships between dietary intake and fecal concentrations of milk fat globule-epidermal growth factor 8 (MFG-E8), and between fecal concentrations of MFG-E8 and markers of intestinal inflammation in infants born preterm.

Fecal samples were collected daily and enteral feedings were sampled weekly. MFG-E8 in enteral feedings and feces, and cytokine concentrations in feces were quantified by enzyme-linked immunosorbent assay.

Results:
--Milk MFG-E8 concentrations were significantly greater in unfortified mother's own milk (MOM) and MOM with human milk fortifier than either donor human milk or preterm formula.

--MFG-E8 concentrations in fecal samples were positively correlated with MFG-E8 concentrations in respective milks.

--High MFG-E8 exposure (more than 60 mL/kg/day of feedings that include MOM or MOM with human milk fortifier) was associated with lower concentrations of proinflammatory cytokines (interleukin-8, tumor necrosis factor-alpha, and monocyte chemoattractant protein-1) and higher concentrations of the anti-inflammatory cytokine interleukin-4 in feces, compared with low MFG-E8 exposure.

In conclusion, preterm infants who were fed MOM had higher levels of MFG-E8 and lower levels of proinflammatory cytokines in their feces than those who were fed other diets or received no feedings.

Source: https://www.jpeds.com/article/S0022-3476(20)31391-3/fulltext
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