Link between Macular Vessel Density and Total Retinal Blood
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In people with primary open-angle glaucoma and visual field loss, there was a connection between macular vessel density and total retinal blood flow. A Study was conducted to report the relationships of macular vessel density metrics and total retinal blood flow in primary open-angle glaucoma (POAG).

The study included a total of 24 POAG and 19 safe control subjects. The inner retinal thickness (IRT), vessel density (VD), and spacing between large and small vessels (SLV, SSV) were all measured using optical coherence tomography and angiography (OCT/OCTA). Total retinal blood flow (TRBF) was measured using Doppler OCT imaging. Automated perimetry was used on POAG patients, and visual field (VF) loss was calculated as a mean deviation.

Results:
--Compared to the control group, POAG group had decreased VD, TRBF, IRT, and increased SLV.

--Decreased VD (Pearson correlation, r=0.51) and increased SLV (Spearman correlation, rs=-0.47) were correlated with decreased TRBF.

--Decreased VD and SSV and increased SLV (rs=-0.71) were associated with decreased IRT.

--Decreased VF MD was correlated with decreased VD, SSV, IRT (r more than 0.53), and with increased SLV (rs=-0.84).

Conclusively, the finding of an association between macular vessel density and total retinal blood flow supports the role of vascular factors in the pathophysiology of POAG.

Source: https://journals.lww.com/glaucomajournal/Abstract/9000/Relationship_Between_Macular_Vessel_Density_and.97569.aspx
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