Link between perioperative red blood cell infusion and deep
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Perioperative red blood cell (RBC) infusion and deep vein thrombosis (DVT) are linked in patients with pelvic or femoral fractures.

A Study was conducted to analyze the time-event relationship between perioperative RBC infusion and DVT in patients with femoral and pelvic fractures after adjusting for confounding factors and to provide reference for optimizing DVT risk factors.

The clinical data of 569 patients with femoral and pelvic fractures who received surgical treatment were retrospectively analyzed. Propensity score matching (PSM) was performed on 20 covariates of DVT. With the formation or progression of DVT after RBC infusion as the end point, the time-event relationship between perioperative RBC infusion and DVT in patients was analyzed by binary logistic regression.

Results:
--After 1:1 PSM of 569 patients included in this study, 126 patients were in the transfusion group and the non-transfusion group, respectively.

--Before PSM, perioperative RBC infusion was associated with DVT formation for femoral and pelvic fractures. This conclusion was still obtained after PSM.

--The risk of DVT in patients with RBC infusion of 2-4U and more than 4U is 1.833 and 2.667 times that of less than 2U, respectively.

--After excluding patients who received preoperative RBC infusion and had DVT formation or progression prior to RBC infusion, perioperative RBC infusion was still associated with the formation of DVT in femoral and pelvic fractures.

In conclusion, RBC perioperative infusion is a cause of DVT, and the risk of DVT is positively linked with RBC infusion in patients with pelvic or femoral fractures.

Source: https://josr-online.biomedcentral.com/articles/10.1186/s13018-021-02510-6
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