Link between the oral microbiome and oesophageal and gastric
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A few studies highlighted the possible link with oesophageal cancer. However, there is a lack of robust epidemiologic data on whether periodontal disease and tooth loss, indicators of oral microbial dysbiosis, are associated with these two cancers.

Here, Researchers prospectively examined the association of history of periodontal disease and tooth loss with the risk of oesophageal and gastric adenocarcinoma in 98 459 women.

Over 22–28 years of follow-up, documented 199 cases of oesophageal adenocarcinoma and 238 cases of gastric adenocarcinoma. History of periodontal disease was associated with a 43% and 52% increased risk of oesophageal adenocarcinoma and gastric adenocarcinoma. Compared to individuals with no tooth loss, the risks of oesophageal and gastric adenocarcinoma for those who lost 2 teeth were also modestly increased. Among individuals with a history of periodontal disease, no tooth loss and losing 1 tooth were equally associated with a 59% increased risk of oesophageal adenocarcinoma compared to those with no history of periodontal disease and no tooth loss. Similarly, the same group of individuals had 50% and 68% greater risk of gastric adenocarcinoma.

Increasing evidence has highlighted the strong scientific rationale for a link between the oral microbiome and oesophageal and gastric cancer. Tannerella forsythia and Porphyromonas gingivalis, as members of the 'red complex' of periodontal pathogens, have been associated with the presence or risk of oesophageal cancer. Together, these data support the importance of oral microbiome in oesophageal and gastric cancer.

Source: https://gut.bmj.com/content/early/2020/06/30/gutjnl-2020-321949
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Dr. A●●●●●l S●●●●a
Dr. A●●●●●l S●●●●a Paediatrics
Great Read👍🏻
Jul 23, 2020Like