Link of Intestinal Microbiota in Children With Symptomatic D
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Dientamoeba fragilis in children has been associated with gastrointestinal symptoms, like abdominal pain and diarrhea. Researchers hypothesized that concomitant microbial alterations, which have been described in other parasitic infections, may be associated with gastrointestinal symptoms in D. fragilis.

In this case-control study performed in 2 centers, 19 children referred to a pediatrician because of gastrointestinal symptoms and with a positive fecal PCR for D. fragilis were included as cases. 19 healthy children were included. They were included as controls and matched for age and gender, selected from an existing cohort of 63 children. A PCR for D. fragilis was performed on fecal samples of the 19 controls to assess D. fragilis carriership in this asymptomatic group. Microbiota was analyzed with the IS-pro technique, and the intestinal microbiota composition and diversity were compared between the 2 groups.

Results:
--Microbiota of children with D. fragilis and gastrointestinal symptoms did not significantly differ in terms of composition and diversity compared with controls, both on phylum and species level.
--In the asymptomatic controls, a positive fecal PCR for D. fragilis was found in 16 of 19.

The presence of clinical symptoms in children with D. fragilis does not seem to be influenced by intestinal microbiota. The pathogenicity of D. fragilis, as well as the pathophysiologic mechanisms underlying the production of gastrointestinal symptoms, needs to be studied.

Source: https://onlinelibrary.wiley.com/doi/10.1002/ppul.25308?af=R
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