Linked color imaging is an useful tool for evaluating endosc
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In the treatment of ulcerative colitis (UC), accurate evaluation of UC activity is important to achieve mucosal healing. Researchers tried to find the clinical utility of linked color imaging (LCI) for the evaluation of endoscopic activity and prediction of relapse in UC patients.

72 consecutive UC patients in remission who underwent colonoscopy between September 2016 and October 2018 were enrolled. The relationship between the presence of redness in white light imaging (WLI) and LCI and histopathological inflammation (Geboes score: GS) at 238 biopsy sites were examined. The presence or absence of planar redness in the entire rectum was also assessed and classified the patients into three groups according to the combination of WLI/LCI: A: WLI-/LCI-, B: WLI-/LCI+, and C: WLI+/LCI+. The relationship between WLI/LCI classification and relapse in 64 patients followed up for more than 12 months from initial colonoscopy was assessed and compared to the Mayo endoscopic subscore (MES).

Results: A GS of 0 or 1 accounted for 89% of WLI/LCI non-redness sites, while a GS of 2 or 3 accounted for 42% of WLI non-redness/LCI redness sites. LCI findings were significantly correlated with GS. During follow-up, 10 patients in group C and four patients in group B relapsed, but none in group A. Non-relapse rates were significantly correlated with WLI/LCI classification, but not with MES.

Conclusively LCI is a useful modality for accurate assessment of endoscopic activity and prediction of relapse in UC by detecting mild inflammation unrecognizable by WLI.

International Journal of Colorectal Disease
Source: https://doi.org/10.1007/s00384-020-03810-9
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