Lipid metabolism is potential 'Achilles' heel' for cancer st
Researchers have discovered a metabolic signature critical for the functioning of "cancer stem cells" that initiate tumor formation. The team also showed how to interfere with this metabolic mechanism in ovarian cancer, inhibiting tumor growth.

The cancer stem cells are resistant to conventional therapies and are responsible for tumor relapse after chemotherapy and development of distant metastases," said Ji-Xin Cheng, a professor in Purdue University's Weldon School of Biomedical Engineering and Department of Chemistry. "Understanding their unique characteristics and vulnerabilities will enable the development of targeted therapies with the ultimate goal of overcoming tumor relapse and metastasis....