Live birth rate with double ovarian stimulation vs follicula
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This study suggests that the live birth rate with double ovarian stimulation is superior to follicular phase ovarian stimulation per started cycle in poor ovarian responders.

A total of 204 poor ovarian responders (PORs) who underwent ovulation induction for in vitro fertilization, cryopreservation of all embryos available, and frozen embryo transfer cycle were retrospectively analyzed. Of those, 146 received single follicular phase ovarian stimulation (FPS), and 58 received double ovarian stimulation (DOS). All viable embryos were cryopreserved and subsequently transferred within 1–6 months.

--The number of oocytes collected and the number of mature oocytes per started cycle was higher in the DOS group compared to the FPS group.

--Clinical pregnancy rate and live birth rate per started cycle were also significantly higher in the DOS group than the FPS group.

--The cancellation rate of embryo transfer due to no viable embryo was significantly lower in the DOS group than in the FPS group.

--In the DOS group, numbers of oocytes, MII oocytes, and cryopreserved blastocysts were significantly higher in the luteal ovarian stimulation compared to follicular ovarian stimulation.

Conclusively, live birth per started cycle with DOS is superior to FPS in PORs. Luteal phase stimulation contributes to improving pregnancy rates in these patients.

The Journal of Obstetrics & Gynecology Research
Source: https://doi.org/10.1111/jog.14871
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