Living With a COVID-19 Case Brings Worse Symptoms And Strong
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In a recent study, researchers found that individuals who lived with people suffering from COVID-19 exhibited greater symptom severity and stronger antibody response. When compared to individuals who were seropositive but did not live with a known COVID-19 case, a greater magnitude of clinical manifestation and immune response was found.

This study suggests that high virus exposure levels contribute to greater disease severity and stronger antibody responses. Such a relation between the exposure dose and the subsequent disease severity has been previously demonstrated experimentally for other respiratory viruses, such as influenza, a respiratory disease.

Additionally, it is also proven that the higher SARS-CoV-2 viral load during acute infection in humans has been linked to greater disease severity. This study's participants screened positive for SARS-CoV-2 in the Screening for Coronavirus Antibodies in Neighborhoods (SCAN) study. To assess the exposure to cohabitants with COVID-19 the participants were asked few questions.

This is an important study where the researchers confirmed that the seropositive individuals who lived with a cohabitant with COVID-19 had substantially greater symptom severity and IgG antibody responses compared to seropositive individuals who did not report having a cohabitant with COVID-19. This study reported that working close to others did not exhibit statistically significant associations with symptom severity or IgG antibody concentrations.