Long-Term Follow-Up Of Recovered Patients With COVID-19: Stu
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SARS-CoV-2 patients are observing persisting symptoms and unexpected, substantial organ dysfunction. Uncertainty remains regarding the possible long-term health sequelae. This is particularly relevant for patients with severe symptoms, including those who required mechanical ventilation during their hospital stay.

The team describes the clinical follow-up of a cohort of 1733 adult patients with COVID-19 who were discharged from the hospital. 6 months after illness onset, 76% of the patients reported at least one symptom that persisted, like fatigue or muscle weakness. More than 50% of patients presented with residual chest imaging abnormalities.

Disease severity during the acute phase was independently associated with the extent of lung diffusion impairment at follow-up, with 56% of patients requiring high-flow nasal cannula, non-invasive ventilation, and invasive mechanical ventilation during their hospital stay having impaired pulmonary diffusion capacity.

13% of the patients who did not develop acute kidney injury during their hospital stay and presented with normal renal function exhibited a decline in eGFR at follow-up. GFR-estimating equations do not enable a sound assessment of renal function, which can be overestimated or underestimated compared with measured GFR.

The study offers a comprehensive clinical picture of the aftermath of COVID-19 in patients who have been admitted to the hospital. Only 4% were admitted to an intensive care unit, rendering the information about the long-term consequences inconclusive.

Clinics dedicated to following up on lasting disabilities in the large number of patients who previously had COVID-19 are opening in many hospitals. This initiative implies a further burden on the health-care system in terms of human and economic resources. This is consistent with the syndemic nature of the CoV-2 pandemic and has implications for the long-term follow-up.

Source:
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)00039-8/fulltext
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