Long-Term Oxygen Therapy for Mild COPD Questioned
The LOTT (Long-Term Oxygen Treatment Trial) study randomly assigned 738 patients with mild COPD at a total of 47 sites to either supplemental oxygen or no supplemental oxygen (N Engl J Med 2016;375[17]:1617-1627). Moderate oxygen deficiency was defined as having blood oxygen saturation of 89% to 93% at rest, or a blood oxygen saturation of below 90% during the six-minute walk test. Patients in the oxygen arm were given 24-hour oxygen if their resting saturation was 89% to 93%, and oxygen only during sleep and exercise if they had desaturation only during exercise. Patients were followed for one to six years....

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