Long Term Visual Acuity May Improve with Higher Injection In
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A Study was conducted to define injection index (ii) and assess its impact on visual acuity (VA) in pigment epithelial detachment from age-related macular degeneration over 5 years.

Injection index is defined as the mean anti-vascular endothelial growth factor (anti-VEGF) injections per year from presentation. A retrospective study of 256 eyes in 213 patients was performed. Patients were stratified by ii (high: more than 9, low: less than 9).

Results:
--Baseline characteristics showed no differences across ii groups. Mean follow-up, in years, was 5.02 for all patients.

--Mean logMAR VA [Snellen VA] were 0.60 and 0.56 at baseline, 0.52 and 0.59 at year 1, 0.45 and 0.67 at year 2, 0.38 and 0.66 at year 3, 0.41 and 0.89 at year 4, and 0.35 and 0.79 at year 5 for the high and low ii groups, respectively.

--Linear regression analysis showed a gain of 0.5 approxETDRS letters with each additional injection per year.

To define injection index (ii) and assess its impact on visual acuity (VA) in pigment epithelial detachment from age-related macular degeneration over 5 years.

Finally, increasing injection index has correlated better mean VA, showing that long-term continuous deletion of VEGF can improve VA in eyes believed to be weak in forecasting.

Source: https://journals.lww.com/retinajournal/Abstract/9000/Pigment_Epithelial_Detachment_in_Age_Related.95480.aspx
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