Long-term air pollution exposure may elevate risk for CV mor
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New data suggest that long-term exposure to fine particulate matter is associated with increased risk for cardiovascular mortality among adults with COPD.

People with chronic obstructive pulmonary disease have increased risk of cardiovascular disease and may be more susceptible to air pollution exposure. However, no study has examined the association between long-term fine particulate matter exposure (less than 2.5 µm in diameter) and risk of cardiovascular events in this potentially vulnerable population.

This study aimed to estimate the association between long-term fine particulate matter and risk of cardiovascular events among adults with chronic obstructive pulmonary disease.

This retrospective cohort study included 169,714 adults with chronic obstructive pulmonary disease who were members of the Kaiser Permanente Northern California health plan. Electronic health record data was linked to 1km modeled PM2.5 exposure estimates. It used Cox proportional hazard models, adjusting for age, sex, race/ethnicity, calendar year, smoking, body mass index, comorbidities, medications, and socioeconomic status. In low exposure analyses, it examined effects below the current regulation limit (12 µg/m3).

Among adults with chronic obstructive pulmonary disease, a 10 µg/m3 increase in 1-year mean fine particulate matter exposure was associated with an elevated risk of cardiovascular mortality. Effects were stronger in low exposure analyses. Fine particulate matter exposure was not associated with acute myocardial infarction or stroke in overall analyses.

Conclusively, long-term fine particulate matter exposure was associated with an increased risk of cardiovascular mortality among adults with chronic obstructive pulmonary disease. Current regulations may not sufficiently protect those with chronic obstructive pulmonary disease.

Source: https://www.atsjournals.org/doi/abs/10.1164/rccm.202007-2901OC
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