Long term high-fat diet expands waistline and shrinks brain
High-fat diet HFD-induced obesity of pR5 transgenic mice expressing P301L mutant human tau generates T2DM. HFD induces glucose intolerance and insulin resistance in pR5 mice. pR5 mice are more vulnerable to HFD-induced obesity compared to WT, especially with increasing age. pR5 mice are more vulnerable to HFD-induced glucose intolerance impairment compared to WT, especially with increasing age. Long-term HFD significantly aggravates depression-like behavior and cognitive deficit in pR5 mice. Long-term HFD aggravates tau hyperphosphorylation in pR5 transgenic mice.

Source: https://link.springer.com/article/10.1007/s11011-022-01029-x
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