Long-term outcomes of Early initiated Antiretroviral therapy
Now open: Certificate Course in Management of Covid-19 by Govt. Of Gujarat and PlexusMDKnow more...Now open: Certificate Course in Management of Covid-19 by Govt. Of Gujarat and PlexusMDKnow more...
In most studies, the virological response is assessed during the first 2 years of antiretroviral treatment initiated in HIV-infected infants. However, early initiation of antiretroviral therapy exposes infants to very long-lasting treatment. Moreover, maintaining viral suppression in children is difficult.

Researchers aimed to assess the virologic response and mortality in HIV-infected children after 5 years of early initiated antiretroviral treatment (ART) and identify factors associated with virologic success.

All 149 children who were still alive after 2 years of early ART were included in the ANRS-12140 Pediacam cohort sample. After 5 years of care, the virologic response was evaluated. The Kaplan-Meier curve was used to estimate the likelihood of preserving virologic performance between 2 and 5 years of ART. At 5 years after starting ART, the immune status and mortality were also investigated. Using logistic regressions, factors associated with a viral load less than 400 copies/mL in children still alive after 5 years on ART were investigated.

Results:
--The viral load after 5 years of early ART was suppressed in 66.8% of the 144 children still alive and in care.

--Among the children with viral suppression after 2 years of ART, the probability of maintaining viral suppression after 5 years of ART was 64.0%.

--The only factor associated with viral suppression after 5 years of ART was achievement of confirmed virological success within the first two years of ART (OR=2.7).

Finally, the poor likelihood of sustaining viral suppression between 2 and 5 years of early initiated ART shows the challenge for parents to prescribe medications to their children on a regular basis. It also emphasized the significance of initial viral suppression in achieving and sustaining long-term virologic performance.

Source: https://bmcpediatr.biomedcentral.com/articles/10.1186/s12887-021-02664-6
Like
Comment
Share