Longitudinal assessment of salivary vitamin D binding protei
Vitamin D is critical for bone physiology. This study finds that optimal Vitamin D Binding Protein (VitDBP) levels are an important factor for significant orthodontic tooth movement.

In this longitudinal study, saliva samples were collected from 73 orthodontic patients for 4 time points for the first six months of orthodontic treatment, along with dental casts at the beginning and the end of the study period. The saliva was measured for VitDBP as a biological marker for bone apposition and clinical tooth movement.

They used the absolute change in Little's Irregularity Index as a quantitative measure for alignment. In addition, they measured the levels of alkaline phosphatase (ALP) in saliva as a marker of bone turnover.

Both low and high VitDBP levels were associated with reduced tooth movement. Significant seasonal changes in VitDBP using a two-season year model were found with lower levels observed in the summer than in the winter.

Conclusively, clinically significant orthodontic tooth movement is associated with an optimal range of VitDBP in saliva. Normal levels of VitDBP correlated with more orthodontic tooth movement, suggesting a "normal" range of salivary content of VitDBP.

BMC Oral Health
Source: https://doi.org/10.1186/s12903-021-01689-8