Low-Dose Prednisolone Shows Subacute Thyroiditis Noninferior
A prospective, randomized, open-label, single-center, parallel-group, controlled, noninferiority study. The researchers randomly assigned 40 adults with subacute thyroiditis to receive either low-dose prednisolone, starting at 15 mg/day for 1 week followed by weekly tapering decrements to daily doses of 10 mg, 5 mg, and 2.5 mg; or regular-dose prednisolone starting at 30 mg/day for the first week followed by tapering decrements to daily doses of 15 mg, 10 mg, 5 mg, and 2.5 mg. 36 of the enrolled patients completed the study and were included in the analysis. Of those patients, 16 received the low-dose regimen, and 20 received the regular-dose regimen. There were no significant differences at baseline between the patients in the two treatment arms. The results showed that a low-dose prednisolone regimen was non-inferior to a regular-dose regimen for treating people with subacute thyroiditis in a prospective, single-center, randomized study that was completed by 36 patients.

Source: https://www.medscape.com/viewarticle/977514?src=rss