Low Levels of Vitamin-D Linked To Development Of Acne
A total of 120 patients with moderate-to-severe acne and 90 age- and sex-matched healthy controls were enrolled in the study. The patients were treated with oral isotretinoin at 0.50–0.75 mg/kg/day and serum vitamin D was measured at baseline and 3 months after the treatment.

Serum vitamin D was insufficient and deficient in 90.50% of cases in comparison with 43.33% of controls (p = 0.001). Serum vitamin D had an inverse correlation with the severity of acne. Following 3 months of oral isotretinoin, there was no significant change in serum vitamin D level (p = 0.127). Vitamin D was low in patients with moderate-to-severe acne in compared with control. Vitamin D level did not change with short-term therapy with oral Isotretinoin.

Source: https://onlinelibrary.wiley.com/doi/abs/10.1111/jocd.14996?campaign=wolearlyview