Low medication adherence is associated with decline in healt
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Health-related quality of life (HRQOL) is an indicator of how a health condition and its treatment affect physical, emotional and social well being. Hypertension is an important modifiable risk factor for cardiovascular disease (CVD), which is associated with poor HRQOL. Given the growing number of older adults with hypertension and at risk for CVD, there is an increasing concern about declining HRQOL in a growing segment of the USA population. Identifying modifiable factors associated with declining HRQOL among older adults may facilitate efforts to address this concern.

The aim of this study was to determine the association of low antihypertensive medication adherence with decline in health-related quality of life (HRQOL) over 1 year.

Researchers used data from older men and women with hypertension (n = 1525) enrolled in the Cohort Study of Medication Adherence among Older Adults. Adherence was measured using the validated self-report four-item Krousel-Wood Medication Adherence Scale (K-Wood-MAS-4) and prescription refill-based proportion of days covered (PDC).

They defined decline in HRQOL as a decrease in Mental Component Summary (MCS) or Physical Component Summary (PCS) score (from the RAND 36-Item Health Survey 1.0 administered at two time points – at the time of adherence assessment and 1 year later) equivalent to the minimal important difference (MID) for each respective summary score, calculated as the average of MID estimates derived from distribution and anchor-based approaches.

Results:
-- The prevalence of low adherence was 38.6% using the K-Wood-MAS-4 and 23.9% using PDC.

-- On the basis of mean MID estimates of 4.40 for MCS and 5.16 for PCS, 21.8 and 25.2% of participants experienced a decline in MCS and PCS, respectively, over 1 year.

-- Low adherence was associated with a decline in MCS for K-Wood-MAS-4, but not PDC.

-- Low adherence was not associated with decline in PCS.

Conclusively, low self-report medication adherence is associated with decline in mental HRQOL over 1 year in older adults with hypertension.

Source: https://journals.lww.com/jhypertension/fulltext/2021/01000/low_medication_adherence_is_associated_with.21.aspx
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