Lower extremity artery calcification is correlated with Oste
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Evidence is presented to demonstrate the correlation between arterial calcification of the lower extremities and the occurrence of osteoporosis in postmenopausal T2DM women, but not in similarly aged T2DM men.

Researchers performed a retrospective cross-sectional study in patients with T2DM. They were assigned into two groups (patients with or without vascular calcification) in both sexes. Clinical characteristics, presence of osteoporosis, and bone metabolic markers were compared. Arterial calcification was determined by ultrasonography examination. Osteoporosis was defined based on the measurements from dual-energy X-ray absorptiometry. The relationship between the lower extremity arterial calcification and the presence of osteoporosis was analyzed. Statistical analysis was performed in SPSS 26.0.

A total of 933 T2DM patients were identified and analyzed.
-A significant association between arterial calcification and osteoporosis was only observed in women, with a higher prevalence of osteoporosis observed in women with calcification (40.8%) than in women without calcification (26.9%).
-Compared to women without calcification, women with calcification had lower bone mineral densities in the hip and femoral neck.
-Ordinal logistic regression analysis showed that women with calcification had a nearly 2-fold increased risk for osteoporosis, even after adjusting for age, duration of T2DM, body mass index, pulse pressure, clearance of creatinine, glycosylated hemoglobin, and fasting C-peptide.
-Similar differences were not identified between men with and without calcification.

Through the study it was concluded that calcification of lower extremity arteries is related with the presence of osteoporosis in postmenopausal T2DM women.

Source: https://link.springer.com/article/10.1007/s00198-020-05775-5
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