Luteoma of Pregnancy Presenting with Severe Maternal Virilis
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Introduction
Pregnancy luteoma is a rare tumor-like lesion of the ovary, first described in 1963 by Dr. Sternberg, that occurs during pregnancy and generally resolves completely after delivery.
It is a benign condition: only in 30% of cases the mass is hormonally active leading to secretion of androgens causing masculinization in mother and female babies.
To date, fewer than 200 cases have been reported in literature and most of the patients were mildly symptomatic.
An accurate diagnosis is fundamental for the management of the mother and fetus since it can be confused with ovarian malignancy.
We report the case of a Caucasian woman with virilisation worsening symptoms in the second trimester of pregnancy.

Case Presentation
A 25-year-old primigravida presented at 28 weeks of gestation with symptoms of facial acne and abdominal and facial hirsutism appearing first at 23 weeks of gestation.

Ultrasound imaging showed a viable fetus with a normal growth and morphology and a 12 × 9?cm right adnexal mass with necrotic areas and low color Doppler signals. The left adnexa was unremarkable. The blood test showed a mild elevated level of transaminases, negative tumoral markers, and elevated serum level of testosterone, SHBG , androstenedione, and DHEAS. A magnetic resonance was proposed but patient declined the study.....

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5021856/
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