Lymphangioma Formation Following Hyaluronic Acid Injection f
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Lymphangiomas are uncommon hamartomas of the lymphatic system. Although usually congenital, they can be acquired due to trauma, inflammation, or lymphatic blockage.

A 27-year-old female presented with a two-year history of linear swellings in her upper lip. These lumps followed the line where HA filler had been injected four years earlier.

Hyaluronidase had previously been used unsuccessfully to remove these lumps. The patient was treated with surgery to excise the lesions. Five masses were excised, and histopathological analysis displayed the presence of variably ectatic lacunae, lined by cells with CD34 expression, a lymph-vascular-endothelial marker. There were also scattered macrophages with CD68 expression in the interstices. These are typical features of a lymphangioma. The patient was satisfied with the excellent aesthetic and functional outcome.

Although rare, this complication can have aesthetic implications for the patient which may require further treatment or surgery to correct.

Source: https://www.cureus.com/articles/48743-lymphangioma-formation-following-hyaluronic-acid-injection-for-lip-augmentation
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