MRI-defined Osteophyte Presence and Concomitant Cartilage Da
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A Study was conducted to describe compartmental frequencies of MRI-defined osteophytes and co-localized cartilage damage and evaluate the associations of osteophyte (OP) size with any ipsicompartmental cartilage damage in knees with incident tibiofemoral radiographic knee osteoarthritis (ROA).

Researchers evaluated knees from the Osteoarthritis Initiative without ROA at baseline that developed ROA during a 4-year interval. Semi-quantitative MRI scoring of osteophytes and cartilage damage was performed at the time point when ROA was diagnosed, defined as Kellgren-Lawrence grade more than 2, using the MOAKS instrument.

The frequencies of maximum osteophyte size and maximum grade of ipsicompartmental cartilage damage were assessed. Generalized estimating equations were used to determine the association of MRI?defined maximum osteophyte size with presence of any (excluding focal superficial defects) ipsicompartmental cartilage damage.

--296 knees that did not have tibiofemoral ROA at the baseline visit but developed ROA during the 48- month observational period were included.

--In the patellofemoral, medial tibiofemoral and lateral tibiofemoral compartments, the most frequent OP grade was 1 (67.6%, 59.1% and 51.7%, respectively), and in the posterior femur it was 0 (51.7%).

--For all compartments except the posterior femur, a linear trend was found between increasing maximum OP size and the presence of any concomitant cartilage damage.

In conclusion, regardless of the size of the concomitant osteophyte, the patellofemoral joint showed more serious cartilage damage than other compartments in this study of knees with incident tibiofemoral ROA. Despite the occurrence or size of concomitant osteophytes, cartilage damage in the posterior femur was uncommon.