Magnitude of Interferon Gamma Release Assay Responses in Chi
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This study assessed the association between quantitative interferon gamma (IFN) gamma response and degree of Mycobacterium tuberculosis exposure, infection and tuberculosis (TB) disease status in children.

Cross-sectional analysis of children exposed to an adult with bacteriologically confirmed TB was completed. IFN gamma values were reported as concentrations and spot forming units for the QuantiFERON-TB Gold In-Tube (QFT-GIT) and T-SPOT.TB, respectively. Random-effects linear regression was used to investigate the relation between the M. tuberculosis contact score, clinical phenotype (TB diseased, infected, uninfected) and IFNgamma?response as outcome, adjusted for relevant covariates.

Results:
Data from 669 children (median age, 63 months; interquartile range, 33–108 months) was analyzed.

--A 1-unit increase in M. tuberculosis contact score was associated with an increase of IFNgamma 0.60 international unit/mL, and IFN gamma spot forming unit 2 counts.

--IFNgamma response was significantly lower among children with M. tuberculosis infection compared with children with TB disease (beta = –1.42) for the QFT-GIT, but not for the T-SPOT.TB.

--This association was strongest among children 2–5 years and absent if less than 2 years.

Finally, IFN gamma response was connected with recent exposure to M. tuberculosis evaluated by QFT-GIT and T-SPOT.TB and was correlated with clinically relevant TB phenotype by QFT-GIT. The size of the gamma reaction. In addition to evaluating the probability of M. tuberculosis infection, IFN gamma readings can also help diagnose children with TB.

Source: https://journals.lww.com/pidj/Abstract/2021/08000/The_Magnitude_of_Interferon_Gamma_Release_Assay.17.aspx
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