Major depressive disorder and cardiometabolic diseases: a bi
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Observational studies have shown a bidirectional association between major depressive disorder (MDD) and cardiometabolic diseases. A two-sample bidirectional Mendelian randomisation (MR) study to assess the causal associations of MDD with type 2 diabetes, coronary artery disease (CAD) and heart failure and vice versa was conducted. This study strengthened the evidence that MDD is a potential risk factor for type 2 diabetes and CAD. Whether MDD is causally related to heart failure needs further study.

Author extracted summary-level data for MDD, type 2 diabetes, CAD and heart failure from corresponding published large genome-wide association studies of individuals mainly of European-descent. In total, 96 SNPs for MDD, 202 SNPs for type 2 diabetes, 44 SNPs for CAD and 12 SNPs for heart failure were proposed as instrumental variables at the genome-wide significance level (p < 5 × 10−8). The random-effects inverse-variance weighted method was used for the main analyses.

Results: Genetic liability to MDD was significantly associated with type 2 diabetes and CAD at the Bonferroni-corrected significance level. The ORs of type 2 diabetes and CAD were respectively 1.26 and 1.16 per one-unit increase in loge odds of MDD. There was a suggestive association between MDD and heart failure. We found limited evidence supporting causal effects of cardiometabolic diseases on MDD risk in the reverse MR analyses.

Conclusively, The present MR study strengthens the evidence that MDD is a potential risk factor for type 2 diabetes and CAD. However, there was no genetic support for a causal effect of type 2 diabetes or CAD on MDD. Whether MDD is causally related to heart failure needs further investigation. Given the high disease burden related to the causal link, it is recommended that MDD prevention, management and treatment should be enhanced for type 2 diabetes prevention.

Source: https://link.springer.com/article/10.1007/s00125-020-05131-6
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