Male, elderly patients with severe COVID-19 may have higher
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Recent research published in the Journal of Clinical Investigation showed that older males who were hospitalized with severe symptoms of COVID-19 can be the best candidates for donating antibody-rich plasma.

Researchers from the Johns Hopkins examined samples of plasma collected from 126 recovered COVID-19 patients - 54% were men and 46% were women with a median age of 42 years. Most of these patients presented with mild to moderate symptoms of COVID-19 and only 10% of them were admitted to the hospital.

Plasma samples were collected 43 days after the patients took their first RT-PCR test. Scientists then conducted various tests to determine the ability of the plasma samples to neutralize COVID-19

Results of the study showed that males with advancing age, who had to be hospitalized due to severe COVID-19, had higher levels of neutralizing antibodies and better IgG responses against SARS-CoV-2.

Patients who were admitted to the hospital with COVID-19 infection had more anti-spike protein antibodies in their plasma and were able to neutralize the virus more effectively.

Also, these antibodies were found in a larger quantity in males than in females.

Scientists further added that a possible explanation for this could be that due to severe disease, the inflammatory response in the body gets accelerated, recruiting more B-cells to fight the infection. This consequently results in more antibody production.

Source: https://www.jci.org/articles/view/142004
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