Malignancies with low fluorodeoxyglucose uptake at PET/CT
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Fluorine 18 fluorodeoxyglucose (FDG) positron emission tomography (PET) is commonly performed for staging and restaging of solid tumours. Although most solid tumours demonstrate high uptake of FDG, many others do not. Low FDG uptake may be due to various reasons, including tumours with low glucose metabolism or low cellularity, improper patient preparation, and small tumour size. The presence of low-level FDG uptake could be a source of scan misinterpretation in these low-cellularity or low-glucose-metabolizing tumours, including low-grade lung adenocarcinomas, renal cell cancers, and mucinous neoplasms.

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