Management of postoperative pancreatic fistula after pancrea
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Postoperative pancreatic fistula (POPF) is a common and critical complication of pancreatoduodenectomy (PD). Open drainage is treatment of choice for POPF.

Appropriate management of POPF is important to reduce the mortality rate after PD, in this study by Surgery, investigators aimed to evaluate an approach for the management of POPF after PD, including the postoperative course.

This retrospective study included 605 consecutive patients who underwent PD. All patients who developed POPF were first managed conservatively, with drainage tubes placed during surgery retained to manage POPF. In cases wherein conservative treatment was unsuccessful, open drainage, followed by continuous negative pressure and continuous irrigation, was used. For open drainage, the surgical wound was opened bluntly under local anesthesia, and the fluid was directly and completely drained.

--The prevalence of POPF of grades B and C was 15.4% and 0.33%, respectively.

--Of these patients, 1 required reoperation, 43 recovered with conservative management only, 47 required open drainage, and 4 required image-guided percutaneous drainage.

--Postoperative hemorrhage with a pseudoaneurysm was identified in 3 patients. The postoperative in-hospital mortality rate was low. The rate of successful POPF management was 98.9%.

In particular, based on high success rate in POPF management, researchers consider open drainage to be a safe primary management method for POPF.

Source: https://doi.org/10.1016/j.surg.2021.01.010
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