Mantle cell lymphoma negative for t(11,14) involving the kid
A 75-year-old non-Hispanic White male with a past medical history significant for hypertension and dyslipidemia, presenting with fever, weight loss, and night sweats. The workup showed markedly elevated white blood cells, multiple enlarged lymph nodes, and a kidney mass. The patient was diagnosed with mantle cell lymphoma with kidney involvement confirmed with a kidney biopsy. His disease was positive for cyclin D1 overexpression despite t(11; 14) absence. The patient received six cycles of alternating vincristine, rituximab, cyclophosphamide, doxorubicin, and prednisone then dexamethasone, high-dose cytarabine, and oxaliplatin, after which he was maintained on ibrutinib and rituximab, with a resolution of symptoms and disease regression.