Maternal antenatal corticosteroid treatment associated with
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According to a study published in JAMA, exposure to maternal antenatal corticosteroid treatment was significantly associated with mental and behavioral disorders in children. These findings may help inform decisions about maternal antenatal corticosteroid treatment.

Maternal antenatal corticosteroid treatment is standard care to accelerate fetal maturation when birth before 34 weeks is imminent. Recently, the expansion of the indications beyond 34 gestational weeks has been debated. However, data about long-term outcomes remain limited, especially among infants who after treatment exposure are born at term.

Of the 674 877 singleton children during the study period, 670 097 were eligible for analysis. The median length of follow-up was 5.8 years. Of the 14 868 corticosteroid treatment–exposed children, 6730 were born at term and 8138 were born preterm; of the 655 229 nonexposed children, 634 757 were born at term and 20 472 were born preterm. Among the 241 621 eligible term-born maternal sibpairs nested within this population, 4128 pairs were discordant for treatment exposure. Treatment exposure, compared with nonexposure, was significantly associated with higher risk of any mental and behavioral disorder in the entire cohort of children, and when sibpairs discordant for treatment exposure were compared with sibpairs concordant for nonexposure. In preterm-born children, the cumulative incidence rate of any mental and behavioral disorder was also significantly higher for the treatment-exposed compared with the nonexposed children, but the HR was not significant.

Conclusively, In this population-based cohort study, exposure to maternal antenatal corticosteroid treatment was significantly associated with mental and behavioral disorders in children. These findings may help inform decisions about maternal antenatal corticosteroid treatment.

Source: https://jamanetwork.com/journals/jama/article-abstract/2766162
Dr. S●●●●y M●●●●●●●●i and 2 other likes this1 share
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Dr. S●●●●v K●●●●●●a
Dr. S●●●●v K●●●●●●a Paediatrics
In a seminar yesterday,for preterm prenatal care of mothers in case of managing the delivery by giving mothers Steroids were advised along with tocolytics. Now with this inference it' s very confusing as to what should we follow and advise and act???
May 24, 2020Like
Dr. R●●●N C●●●●●A G●●●a
Dr. R●●●N C●●●●●A G●●●a Obstetrics and Gynaecology
Difficult to understand the practice of routine administration of cortisol to patients even after 34 weeks.
May 25, 2020Like