Maternal economic vulnerability and childhood neurodevelopme
The study suggests that maternal economic vulnerability has a negative effect on childhood neurodevelopment.

The study assesses the relationship between economic vulnerability during pregnancy and childhood neurodevelopment.

This is a secondary analysis of two parallel multicenter, randomized, controlled trials of administration of levothyroxine to pregnant individuals with subclinical hypothyroidism or hypothyroxinemia in the United States. All participants who delivered a live, nonanomalous neonate and completed the WPPSI-III at 5 years of life and the Bayley-III test at 2 years were included. The primary outcome is the WPPSI-III score. Secondary outcomes included Bayley-III subtest scores. Of 955 participants who met inclusion criteria, 406 were considered economically vulnerable.

- In bivariate analysis, the WPPSI-III score and Bayley-III subtest scores were significantly lower among children of the economically vulnerable.

- For the WPPSI-III, Bayley-III cognitive subtest, and Bayley-III language subtest scores, the associations between economic vulnerability and lower childhood neurodevelopmental scores were primarily seen only among those who were married or completed more than high school education.

- A similar pattern was noted when restricting the income criteria for economic vulnerability to less than 100% of the federal poverty level.

Conclusively, economic vulnerability during pregnancy is associated with an increased risk of adverse neurodevelopmental outcomes in their children at 2 and 5 years of life, particularly among those who are married or completed more than high school education.

Obstetrics & Gynecology