Maternal effects induced by oral digoxin during treatment of
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The aim of this study is to evaluate the prevalence of maternal complications derived from digoxin treatment and its relationship with digoxinemia, as well as its occurrence in relation to the different treatment doses and therapeutic schemes used.

There were 10 cases eligible. During treatment, at least one symptom or sign was present in 30% of cases, being in all cases digestive symptoms. In all those cases, the digoxin level was higher than established as a therapeutic threshold (2 ng/mL), and all reversed within a maximum of 48 hours after the dose decrease. Digoxinemia overdosing (more than 2 ng/mL) was observed in 6 women (60%), one of which reached the toxicity range (more than 3 ng/mL). In all cases, the normal range was achieved decreasing the dose of digoxin 0.25 mg every 24 h. No patient developed side effects with digoxinemia below 2 ng/mL. No electrocardiographic abnormalities appeared during treatment.

Digoxin is a safe treatment for the management of fetal tachyarrhythmias. Side effects appear frequently when serum digoxin level is over 2 ng/mL, but they are usually mild and self-limited. However, it remains advisable to monitor electrocardiographic changes and digoxinemia through the whole therapy to prevent serious complications related to digoxin toxicity.

Source: https://www.ejog.org/article/S0301-2115(20)30769-7/fulltext?rss=yes
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