Mechanical Bowel Obstruction Due to Localized Extensive Amyl
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Abstract :
Amyloidosis is a disorder caused by extracellular deposition of insoluble protein fibrils in various tissues. Colonic amyloidosis is a rare clinical manifestation which can mimic tumor, inflammatory bowel disease, or ischemic colitis. The most common symptoms of colonic amyloidosis include bleeding, ulceration, diarrhea, and abdominal pain. However, colonic obstruction due to extensive submucosal amyloidosis is extremely rare. Considering the wide variety of symptoms and potentially effected organs, the diagnosis can be challenging particularly in emergent conditions. In this paper, a case with mechanic bowel obstruction due to extensive amyloidotic involvement of the left colon is presented.

Case :
A 76-year-old male patient was admitted to the emergency unit with a 10-day history of constipation, progressive abdominal distention, and discomfort. For several years, he had suffered from difficulties of defecation and intermittent rectal bleeding. Very recently, he had undergone full colonoscopy a month prior to presentation. Severe luminal narrowing and wall thickening were detected in the left colon and also the colonic mucosa was too fragile and friable due to excessive edema. Multiple biopsy was taken during colonoscopy, and histopathological analyses unveiled fibrosis, congestion, and nonspecific findings of chronic inflammation......

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425743/
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