Men With COVID-19 Three Times More Likely To Need Intensive
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Men infected with COVID-19 are three times more likely to require intensive care than women and are at significantly higher risk of dying from the virus, scientists said. Researchers analyzed over three million confirmed coronavirus cases from 46 countries and 44 states in the US between January 1 and June 1, 2020.

They found that the risk of SARS-Cov-2 infection was the same for women and men. Sex differences in both the innate and adaptive immune system have been previously reported and may account for the female advantage in COVID-19.

Women naturally produce more type I interferon proteins that limit cytokine storm which is believed to play a role in provoking severe forms of COVID-19. Also female oestradiol boosts the response of T cells which kill infected cells and increases the production of antibodies, the study said. In contrast, the male sex hormone testosterone suppresses the immune system.

Sex-based differences in co-morbidities associated with severe COVID-19 may put men at outsize risk. In addition, the authors noted the similarity in the proportions of women and men with hypertension and diabetes globally.

Source:
https://www.nature.com/articles/s41467-020-19741-6
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