Meningeal seeding from glioblastoma multiforme treated with
Case report:
A 41-year-old male patient with an unremarkable past medical history presented with blurred vision, intermittent headache, and low-grade fever and was admitted to our hospital. Neurological examination revealed homonymous right hemianopsia. Hemogram, blood chemistry, and urine laboratory data were normal, with the exception of leukocytosis [White blood cell (WBC), 12.4 × 109/L]. Head computed tomography (CT) and magnetic resonance imaging (MRI) demonstrated a well-enhanced mass lesion in the left parieto-occipital lobe with marked perifocal brain edema, which compressed lateral ventricles, and another smaller lesion located anterior to the main mass (Fig. 1A and B). The patient underwent a craniotomy and partial tumor excision, and the satellite lesion was left untouched. Pathological examination of the tumor identified it as GBM. The methylation status of the O6-methylguanine-DNA methyltransferase (MGMT) promoter in the GBM sample was analyzed using methylation-specific PCR, and the MGMT promoter was found to be unmethylated....