Mental Health During Pregnancy and Postpartum in Mothers Wit
Environmental Determinants of Islet Autoimmunity (ENDIA) study is a prospective pregnancy-birth cohort study involving over 1,400 women whose offspring have a first-degree relative, either a mother, father, or sibling, with T1D. Given their family history, all offspring in the ENDIA study will have an increased lifetime risk of developing T1D. Over 700 mothers in the ENDIA study were included in the substudy, representing a participation rate of 86% of the eligible cohort. A further 500 subjects were ineligible to participate, as they were recruited prior to the introduction of the mental health analyses.

The mental health of mothers with T1D is compared with that of mothers without T1D but whose offspring have a father or sibling with T1D. Mental health of mothers was assessed in the third trimester of pregnancy and postpartum period using two validated mental health questionnaires. Data regarding sociodemographic factors, history of mental health disorders, psychotropic medication use, and self-reported physical activity level were collected. The interaction between mental health scores and glycemic control in late pregnancy was also explored.

The findings of the current study are important for health care providers involved in the care of women with T1D during pregnancy for two reasons. First, the study does not suggest a difference in EPDS and PSS scores. This finding may be considered an endorsement of the increased multidisciplinary support women with T1D received during pregnancy.