Merck's MK-4482 pill could be new, big hope to treat COVID-1
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Merck & Co.’s experimental antiviral pill has the potential to unseat the handful of authorized treatments for Covid-19, that are already weighed down by questions about their effectiveness.

• Phase 2 results from two studies of Merck’s antiviral pill — one in hospitalized patients with Covid-19 and one in outpatients — are expected in the next few weeks.

• If those results “are positive and arrive in a timely manner, we believe Merck could begin phase 3 trials in September, which could support an emergency use authorization before year-end," SVB Leerink analyst Daina Graybosch wrote in a note.

• MK-4482 pill stops the virus from replicating. It was discovered by scientists at Emory University and is being tested with collaborator Ridgeback Biotherapeutics LP.

• The pill form gives it an edge over Gilead Sciences Inc.’s remdesivir, now known as Veklury, as well as convalescent plasma, a treatment that the Food and Drug Administration has given the go-ahead for widespread use.

• “We have secured manufacturing capability to produce many millions of doses of the drug before the end of this year,” said Roger M. Perlmutter, president of Merck Research Laboratories.

• The medicine also appeared active in lab tests against viruses with mutations that made them resistant to Veklury, he said.

• Merck plans to kickoff two new pivotal trials in September, one for outpatients and one for those hospitalized. A large phase 2 outpatient study under the auspices of the National Institute of Allergy and Infectious Diseases is also in the works.

Dr. T●●●●z H●●●●●●i and 12 others like this6 shares
Dr. S●●●●h C●●●●●●●i
Dr. S●●●●h C●●●●●●●i Family Medicine
Keeping hope alive!
Aug 28, 2020Like
Dr. V●●●●●●j D●●●i
Dr. V●●●●●●j D●●●i Legal Medicine
It may be possible to control the COVID19 situation better, partly by informing the people that even non-patients might have been already infected by COVID19 infection and that some persons moving out may be already infected but in their pre symptomatic condition. Most importantly, use cloth masks, wash & reuse. Who knows about the absolute safety of the masks which are available and that they are already not infected, may be while getting transported. My suggestion: Absolute caution is necessary in these situations; please don' t take risks.... Read more
Aug 29, 2020Like